NCIt definition : An extremely rare skin disorder usually inherited in an autosomal recessive pattern
and caused by mutation(s) in the TMC6 or TMC8 gene, encoding transmembrane channel-like
protein 6 and transmembrane channel-like protein 8, respectively. It is characterized
by chronic human papillomavirus infection. Patients develop papillomatous wart-like
lesions and pigmented plaques on the skin. It predisposes to cutaneous carcinomas,
especially in situ and invasive squamous cell carcinomas.;