Preferred Label : IL-10 Immunomodulator MK-1966;
NCIt definition : An agent that downregulates the activity of the anti-inflammatory cytokine human interleukin-10
(IL-10), with potential immunomodulating and antineoplastic activities. Upon administration,
IL-10 immunomodulator MK-1966 blocks the activity of IL-10 and may abrogate the IL-10-induced
immunosuppressive tumor microenvironment. This activates cell-mediated immunity against
cancer cells, increases cytokine production, including interferon-gamma (IFN-g), decreases
T regulatory cell (Treg) activity, and induces a tumor-specific cytotoxic CD8 T-cell-mediated
immune response, which enhances tumor cell death.;
Molecule name : MK-1966; MK 1966;
NCI Metathesaurus CUI : CL507902;
Origin ID : C126840;
UMLS CUI : C4287732;
Semantic type(s)
- concept_is_in_subset
