Preferred Label : BET Bromodomain Inhibitor ZEN-3694;
NCIt synonyms : BETi ZEN-3694; ZEN003694;
NCIt definition : An orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family
of proteins, with potential antineoplastic activity. Upon oral administration, the
BET inhibitor ZEN-3694 binds to the acetylated lysine recognition motifs in the bromodomains
of BET proteins, thereby preventing the interaction between the BET proteins and acetylated
histones. This disrupts chromatin remodeling and gene expression. Prevention of the
expression of certain growth-promoting genes may lead to an inhibition of proliferation
in BET-overexpressing tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and
BRDT, are transcriptional regulators that play an important role during development
and cellular growth.;
Molecule name : ZEN 3694; ZEN-3694;
NCI Metathesaurus CUI : CL507898;
Origin ID : C126805;
UMLS CUI : C4287690;
Semantic type(s)
- concept_is_in_subset
- has_target
