Preferred Label : Phytochlorin Sodium-Polyvinylpyrrolidone Complex;
NCIt synonyms : Chlorin E6-polyvinylpyrrolidone; Chlorin E6/PVP; Chlorin E6-PVP;
NCIt definition : A photosensitizer composed of the sodium salt form of chlorin e6 and its derivatives
complexed with a low-molecular weight polyvinylpyrrolidone (PVP) polymer component,
with diagnostic and antineoplastic activities upon photodynamic therapy (PDT). Upon
intravenous administration, the photosensitizer phytochlorin-PVP sodium complex preferentially
accumulates in hyperproliferative tissues, such as tumors. Local application of light
with a certain wavelength to the tumor site results in the absorption of light by
this agent leading to its photoactivation. This results in a photodynamic reaction
between phytochlorin and oxygen, which causes the production of reactive oxygen species
(ROS), including singlet oxygen molecules, the superoxide ion, and other cytotoxic
free radicals. The formation of ROS induces free radical-mediated oxidative DNA damage
followed by apoptosis of tumor cells. Chlorin e6-PVP is able to penetrate deeply into
tissues and is therefore able to treat hard-to-reach tumors.;
Drug name : Photolon; Fotolon;
Molecule name : BLC-1013;
Origin ID : C126802;
UMLS CUI : C4288393;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
