Preferred Label : Trofosfamide;
NCIt synonyms : 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide; N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; N,N,N'-tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide;
NCIt related terms : 2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide,
( )-; Trilophosphamide; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide,
(-)-; Trofosfamid; Z 4828; Ixoten; A-4828; Trophosphamide; Z-4828;
NCIt definition : An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide
(TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO),
which is then metabolized by liver cytochrome P450s to the active isophosphoramide
mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in
inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis.;
UNII : H64JRU6GJ0;
InChIKey : UMKFEPPTGMDVMI-UHFFFAOYSA-N;
CAS number : 22089-22-1;
Drug name : Ixoten; Genoxal Trofosfamida;
Molecule name : A-4828; Z-4828;
Chemical formula : C9H18Cl3N2O2P;
NSC code : 109723;
Codes from synonyms : NSC0109723; NSC0314927; NSC0314928; 120837;
Origin ID : C1268;
UMLS CUI : C0077375;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
