Preferred Label : Pidnarulex;
NCIt synonyms : 2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide; RNA Pol I Inhibitor CX5461; 2-(4-Methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide; 5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-; Pol I Inhibitor CX5461;
NCIt definition : An orally bioavailable inhibitor of RNA polymerase I (Pol I), with potential antineoplastic
activity. Upon oral administration, pidnarulex selectively binds to and inhibits Pol
I, prevents Pol I-mediated ribosomal RNA (rRNA) synthesis, induces apoptosis, and
inhibits tumor cell growth. Pol I, the multiprotein complex that synthesizes rRNA,
is upregulated in cancer cells and plays a key role in cell proliferation and survival.
Hyperactivated rRNA transcription is associated with uncontrolled cancer cell proliferation.;
UNII : 3R4C5YLB9I;
InChIKey : XGPBJCHFROADCK-UHFFFAOYSA-N;
CAS number : 1138549-36-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1138549-36-6
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G-SRS /a ;
Molecule name : CX-5461;
Origin ID : C126798;
UMLS CUI : C5446303;
Semantic type(s)
- UMLS correspondences (same concept)
- CX 5461 [MeSH Supplementary Concept]
- concept_is_in_subset
