Preferred Label : Autologous Tumor-associated Peptide Antigen-pulsed Dendritic Cell Vaccine;
NCIt synonyms : Autologous Tumor Associated Peptide Antigen-pulsed DC Vaccine KiroVAX; Autologous TAPA-pulsed DC Vaccine KiroVAX; Autologous TAPA loaded DC Vaccine;
NCIt definition : A dendritic cell (DC)-based cancer vaccine composed of autologous DCs pulsed with
specific tumor-associated peptide antigens (TAPA), with potential immunostimulatory
and antineoplastic activities. Upon administration, autologous TAPA-pulsed DC vaccine
exposes the immune system to the specific TAPAs, which may result in cytotoxic T-lymphocyte
(CTL)-mediated immune responses against the TAPA-expressing cancer cells. This leads
to cancer cell lysis. This vaccine is specific towards peptides derived from the following
proteins: sperm autoantigenic protein 17 (SP17), ropporin, A-kinase anchor protein
4 (AKAP4), pituitary tumor-transforming 1 (PTTG1) and SPANX family member B (SPANX-B).;
Drug name : KiroVAX;
NCI Metathesaurus CUI : CL507890;
Origin ID : C126797;
UMLS CUI : C4289949;
Semantic type(s)
- concept_is_in_subset
