Preferred Label : Anti-LGR5 Monoclonal Antibody BNC101;
NCIt synonyms : ET-101;
NCIt definition : A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein
coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration,
the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby
inhibiting LRG5-mediated signal transduction pathways. This prevents proliferation
of LRG5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a
cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a
key role in CSC proliferation and survival.;
Molecule name : BNC-101;
NCI Metathesaurus CUI : CL507886;
Origin ID : C126794;
UMLS CUI : C4287661;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
