Preferred Label : Kava-based Supplement;
NCIt synonyms : Kavalactones-based Supplement; Kava Supplement; Flavokavains A and B-free Kava Supplement; AB-free Kava; Flavokavain A/Flavokavain B-free Kava Supplement; Flavokavains A/B-free Kava Supplement;
NCIt definition : A Kava supplement derived from Piper methysticum and containing high amounts of kavalactones,
with potential cancer preventative and anxiolytic activities and that may be used
to facilitate tobacco cessation. Upon oral administration, the kava-based supplement
may affect the metabolism of certain carcinogens, presumably because of the kavalactones
present in this product. This increases detoxification of the carcinogens and may
suppress carcinogen-induced DNA damage and may lower the risk of carcinogenesis. Intake
of the kava-based supplement may also suppress stress-mediated protein kinase A (PKA)
activation, and reduces plasma cortisol levels. This may induce relaxation, may relief
stress and anxiety, improve sleep, and may help reduce tobacco use and tobacco dependence,
and may ultimately decrease the risk of tobacco-associated lung carcinogenesis. The
Kava-based supplement is free of flavokavains A and B, which are potential hepatotoxic
ingredients in kava.;
NCI Metathesaurus CUI : CL507901;
Origin ID : C126793;
UMLS CUI : C4288857;
Semantic type(s)
- Food [UMLS semantic type]
- concept_is_in_subset
