Preferred Label : Apilimod Dimesylate Capsule;
NCIt definition : A capsule containing the dimesylate salt form of apilimod, an inhibitor of the class
III PI kinase phosphatidylinositol-3-phosphate 5-kinase (PIKfyve), with potential
antineoplastic and immunomodulatory activities. Upon oral administration of apilimod
dimesylate capsule, apilimod selectively binds to and inhibits PIKfyve. The inhibition
leads to disruption of PIKfyve-mediated signal transduction pathways and eventually
inhibits tumor cell growth in PIKfyve-overexpressing tumor cells. Also, PIKfyve inhibition
by apilimod inhibits the toll-like receptor (TLR)-induced production of various cytokines,
including interleukin-12 (IL-12) and IL-23, thereby preventing IL-12/IL-23-mediated
immune responses. PIKfyve, a lipid kinase dysregulated in various tumor types, plays
a key role in TLR signaling and tumor cell migration, proliferation and survival.;
Molecule name : LAM-002A; LAM 002A;
NCI Metathesaurus CUI : CL503772;
Origin ID : C126661;
UMLS CUI : C4289965;
Semantic type(s)
- concept_is_in_subset
- has_target
