Preferred Label : Fluorine F 18 Dabrafenib;
NCIt synonyms : [F18]dabrafenib;
NCIt related terms : DABRAFENIB F-18;
NCIt definition : A radioconjugate containing dabrafenib, a tyrosine kinase inhibitor of the V600 mutated
version of the B-raf (BRAF) protein and labeled with the positron-emitting isotope
fluorine F 18 with potential prostate tumor imaging upon positron emission tomography
(PET). Upon administration, the dabrafenib moiety of fluorine F 18 dabrafenib specifically
targets and binds to the BRAF V600-mutated form, expressed on tumor cells, thereby
allowing the visualization of tumor cells expressing BRAF V600 upon PET. BRAF is constitutively
activated in a variety of cancers due to BRAF gene mutations.;
UNII : M9WIX3U8T4;
NCI Metathesaurus CUI : CL503767;
Origin ID : C126653;
UMLS CUI : C4287880;
Semantic type(s)
- concept_is_in_subset
