Preferred Label : Sustained-release Mitomycin C Hydrogel Formulation UGN-101;
NCIt synonyms : Sustained-release Mitomycin C Gel Formulation; RTGel with MMC; RTGel with Mitomycin C; SR Mitomycin C;
NCIt related terms : Sustained-release Mitomycin C Hydrogel Formulation;
NCIt definition : A sustained-release (SR) hydrogel polymer-based formulation containing the antineoplastic
antibiotic mitomycin C (MMC), with potential antineoplastic activity. Upon local administration
of the SR MMC hydrogel formulation to the upper urinary tract via a ureteral catheter,
the gel solidifies and deposits MMC locally to prevent the excretion of this chemotherapeutic
agent via urinary flow. In turn, MMC alkylates DNA, and produces interstrand DNA cross-links,
thereby inhibiting DNA synthesis. Due to its reverse thermal-gelation properties,
this gel is able to stay in a liquid state at cold temperatures and solidifies at
body temperature. This allows for increased accumulation of MMC locally in the upper
urinary tract which leads to increased efficacy compared to standard intravesical
delivery of MMC for upper tract urothelial carcinoma (UTUC).;
Drug name : Mitogel;
Molecule name : MP77-08; UGN-101;
NCI Metathesaurus CUI : CL503759;
Origin ID : C126642;
UMLS CUI : C5235385;
Semantic type(s)
- concept_is_in_subset
