" /> Simurosertib - CISMeF





Preferred Label : Simurosertib;

NCIt synonyms : Cell Division Cycle 7 Inhibitor TAK-931; Thieno(3,2-d)pyrimidin-4(3H)-one, 2-(2S)-1-Azabicyclo(2.2.2)oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-;

NCIt definition : An orally bioavailable inhibitor of cell division cycle 7 (cell division cycle 7-related protein kinase; CDC7), with potential antineoplastic activity. Upon administration, simurosertib binds to and inhibits CDC7; this prevents the initiation of DNA replication during mitosis, which causes cell cycle arrest and induces apoptosis. This inhibits cell growth in CDC7-overexpressing tumor cells. CDC7, a serine/threonine kinase and cell division cycle protein, is overexpressed in a variety of cancers and plays a key role in the activation of DNA replication and the regulation of cell cycle progression.;

UNII : LST350G3XU;

InChIKey : XGVXKJKTISMIOW-ZDUSSCGKSA-N;

CAS number : 1330782-76-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1330782-76-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TAK-931; TAK 931;

NCI Metathesaurus CUI : CL505074;

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12/05/2024


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