" /> Simurosertib - CISMeF





Preferred Label : Simurosertib;

NCIt synonyms : Cell Division Cycle 7 Inhibitor TAK-931; Thieno(3,2-d)pyrimidin-4(3H)-one, 2-(2S)-1-Azabicyclo(2.2.2)oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-;

NCIt definition : An orally bioavailable inhibitor of cell division cycle 7 (cell division cycle 7-related protein kinase; CDC7), with potential antineoplastic activity. Upon administration, simurosertib binds to and inhibits CDC7; this prevents the initiation of DNA replication during mitosis, which causes cell cycle arrest and induces apoptosis. This inhibits cell growth in CDC7-overexpressing tumor cells. CDC7, a serine/threonine kinase and cell division cycle protein, is overexpressed in a variety of cancers and plays a key role in the activation of DNA replication and the regulation of cell cycle progression.;

UNII : LST350G3XU;

InChIKey : XGVXKJKTISMIOW-ZDUSSCGKSA-N;

CAS number : 1330782-76-7;

Molecule name : TAK-931; TAK 931;

NCI Metathesaurus CUI : CL505074;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
09/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.