Preferred Label : Alobresib;
NCIt synonyms : (2-Cyclopropyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)-1hbenzimidazol-4-yl)(dipyridin-2-yl)methanol;
NCIt definition : An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family
of proteins, with potential antineoplastic activity. Upon oral administration, alobresib
binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins,
thereby preventing the interaction between the BET proteins and acetylated histones.
This disrupts chromatin remodeling and gene expression. Prevention of the expression
of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing
tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional
regulators that play an important role during development and cellular growth.;
UNII : 3QBL0BLP3D;
InChIKey : CMSUJGUHYXQSOK-UHFFFAOYSA-N;
CAS number : 1637771-14-2;
Molecule name : GS 5829; GS-5829;
NCI Metathesaurus CUI : CL505073;
Origin ID : C126640;
UMLS CUI : C5139787;
Semantic type(s)
- concept_is_in_subset
- has_target
