NCIt definition : A triphenylmethane-based dye and an inhibitor of nicotinamide adenine dinucleotide
phosphate (NADP ) oxidase 4 (NOX4), with potential anti-invasive and anti-oxidative
activities. Upon administration, imipramine blue (IB) inhibits the activity of NOX4
and prevents NOX4-mediated cell signaling. This prevents the formation of NOX4-mediated
reactive oxygen species (ROS), abrogates the ROS-induced inhibition of protein tyrosine
phosphatase (PTP) activation, and induces both G2/M cell cycle arrest and apoptosis.
NOX4, an enzyme belonging to the NOX family of proteins, promotes the production of
ROS and plays a key role in the suppression of PTP activation; it is upregulated in
a variety of cancers.;
Automatic exact mappings (from CISMeF team)