Trioxifene - CISMeF

Preferred Label : Trioxifene;

NCIt synonyms : (3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl) Methanone;

NCIt definition : A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen.;

UNII : R0130F043H;

InChIKey : IHGLINDYFMDHJG-UHFFFAOYSA-N;

CAS number : 63619-84-1;

Chemical formula : C30H31NO3;

Details

Origin ID

C1266;

UMLS CUI

C0077238;

Currated CISMeF NLP mapping
- trioxifene [MeSH concept]
- trioxifene [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- trioxifene [MeSH concept]
- trioxifene [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Trioxifene Mesylate [NCIt concept]
is_free_acid_or_base_form_of
- Trioxifene Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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