Preferred Label : Lamellar Body Mimetic Mouth Spray LMS-611;
NCIt synonyms : RIX-LMS-611x-20;
NCIt definition : A suspension-based oral spray containing multilamellar lipid vesicles in which the
lipids mimic the lipidic composition of endogenous extra-alveolar lamellar bodies,
with muco-restorative and protective activity against radiotherapy (RT)-induced xerostomia
(RIX). Upon sublingual administration of the lamellar body mimetic LMS-611 using a
spray, the lipids in this agent mimic the natural secretions of endogenous lamellar
bodies. This makes mucus more fluid and may prevent dryness of the mouth. This restores
saliva functions and makes it easier to chew, swallow and talk, and also prevents
xerostomia-induced infections, tooth decay and tooth enamel decay. RT decreases saliva
secretion by causing the destruction of the parotid and submandibular serous salivary
glands and lamellar bodies. This results in thicker and more visco-adhesive saliva,
which causes various xerostomia-induced symptoms; intact lamellar bodies maintain
the fluidity of mucus and lubricate the mouth.;
Drug name : Visco-ease;
Molecule name : LMS-611; OXB/1-20;
NCI Metathesaurus CUI : CL504899;
Origin ID : C126333;
UMLS CUI : C4287723;
Semantic type(s)
- concept_is_in_subset
