Trilostane - CISMeF

Preferred Label : Trilostane;

NCIt synonyms : 2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one; (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile; 4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile;

NCIt definition : A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04);

NCIt note : This drug has been removed from the US market in 1994.;

UNII : L0FPV48Q5R;

InChIKey : KVJXBPDAXMEYOA-CXANFOAXSA-N;

CAS number : 13647-35-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 13647-35-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Desopan; Modrastane; Modrenal;

Molecule name : WIN 24540; WIN 24,540;

Chemical formula : C20H27NO3;

ChEBI ID : CHEBI:32260;

Codes from synonyms : 50561;

Details

Origin ID

C1263;

UMLS CUI

C0077144;

Automatic exact mappings (from CISMeF team)
- Trilostane [ICHI extension code]
Currated CISMeF NLP mapping
- Product containing trilostane (medicinal product) [SNOMED CT concept]
- Trilostane [ICD-11 Extension code]
- Trilostane (substance) [SNOMED CT concept]
- trilostane [Substance BNPC]
- trilostane [MeSH concept]
- trilostane [MeSH Supplementary Concept]
- trilostane [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing trilostane (medicinal product) [SNOMED CT concept]
- Trilostane [ICD-11 Extension code]
- Trilostane (substance) [SNOMED CT concept]
- trilostane [ATC Code]
- trilostane [Substance BNPC]
- trilostane [MeSH concept]
- trilostane [SNOMED Notion]
- trilostane [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- trilostane [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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