Preferred Label : Neutrophil Activation Probe Imaging Agent;
NCIt synonyms : NAP; NAP Imaging Agent;
NCIt definition : A fluorescence imaging agent composed of a fluorescent agent linked, via a human neutrophil
elastase (HNE) cleavable peptide, to a dequencher molecule, with imaging activity
for diagnostic purposes. Upon local administration, the neutrophil activation probe
(NAP) imaging agent, initially quenched, is quickly taken up by activated neutrophils.
In turn, the HNE expressed by these cells, specifically cleaves the linker and dequenches
the fluorescent agent. The activated fluorescent moiety allows for visualization of
activated neutrophils and HNE activity upon using a fluorescence imaging device. Activated
neutrophils are upregulated at sites of inflammation and in inflammation-induced cancers,
and express high levels of HNE.;
NCI Metathesaurus CUI : CL504854;
Origin ID : C126277;
UMLS CUI : C4283878;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
