Preferred Label : Anti-LAMP1 Antibody-drug Conjugate SAR428926;
NCIt synonyms : Anti-LAMP1 ADC SAR428926; ADC SAR428926;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a monoclonal antibody against lysosome-associated
membrane protein 1 (LAMP1) conjugated, via the disulfide-containing cleavable linker
N-succinimidyl-4-(2-pyridyldithio)butyrate (SPDB), to the cytotoxic maytansinoid DM4,
with potential antineoplastic activity. Upon administration of anti-LAMP1 ADC SAR428926,
the anti-LAMP1 monoclonal antibody moiety targets and binds to the cell surface antigen
LAMP1. After antibody-antigen interaction and internalization, the SPDB linker is
selectively cleaved by proteases in the cytosol and the DM4 moiety is released. DM4
binds to tubulin and disrupts microtubule assembly/disassembly dynamics, thereby inhibiting
both cell division and cell growth of LAMP1-expressing tumor cells. LAMP1, overexpressed
on a variety of cancer cells, plays a key role in cell-cell adhesion and migration.
The SPDB linker is resistant to cleavage in the bloodstream, which may increase stability
and reduce toxicity.;
Molecule name : SAR428926;
NCI Metathesaurus CUI : CL504852;
Origin ID : C126275;
UMLS CUI : C4287712;
Semantic type(s)
- concept_is_in_subset
