Preferred Label : Fluorine F 18 Clofarabine;
NCIt synonyms : 18F-CA; Cl-18F-ara-A; [18F]-Clofarabine; 18F-Clofarabine; 2-Chloro-9-(2'-deoxy-2'-18F-fluoro-beta-D-arabinofuranosyl)adenine;
NCIt definition : A radioconjugate composed of the nucleoside analog and deoxycytidine kinase (DCK)-dependent
pro-drug clofarabine (Cl-F-ara-A) linked to the radioisotope fluorine F 18, with potential
imaging activity using positron emission tomography/computed tomography (PET/CT).
Upon administration of fluorine F 18 clofarabine, the clofarabine moiety is preferentially
taken up by and accumulates in cells with dysregulated nucleoside metabolism, including
tumor cells expressing high levels of DCK. The clofarabine moiety is phosphorylated
by DCK into its active triphosphate form, Cl-F-ara-ATP. The 18F moiety can be visualized
by PET imaging. As many nucleoside analog prodrugs are chemotherapeutic agents that
require DCK for their phosphorylation and activation, fluorine F 18 clofarabine can
potentially be used as a marker to measure DCK activity and to predict the chemotherapeutic
efficacy of DCK-dependent prodrugs. DCK, a rate-limiting enzyme in the deoxyribonucleoside
salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid
and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes.
Compared to other nucleoside analogs, clofarabine is not susceptible to deamination
by cytidine deaminase (CDA).;
NCI Metathesaurus CUI : CL504701;
Origin ID : C126106;
UMLS CUI : C4287666;
Semantic type(s)
- concept_is_in_subset
