Preferred Label : Efprezimod Alfa;
NCIt synonyms : CD24 Extracellular Domain-IgG1 Fc Domain Recombinant Fusion Protein CD24Fc; SACCOVID; CD24Fc; CD24Fc CD24IgG;
NCIt definition : A recombinant fusion protein composed of the extracellular domain of the mature human
glycoprotein CD24 linked to a human immunoglobulin G1 (IgG1) Fc domain, with potential
immune checkpoint inhibitory, anti-inflammatory and antineoplastic activities. Upon
administration, efprezimod alfa binds to injured cell components, also called DAMPs
(Danger-Associated Molecular Patterns), thereby preventing the interaction of DAMPs
with toll-like receptors (TLRs) and inhibiting both nuclear factor-kappa B (NFkB)
activation and secretion of inflammatory cytokines. In addition, efprezimod alfa binds
to and activates Siglec G/10, a sialic acid-binding immunoglobulin-type lectin, and
stimulates SHP-1-mediated inhibitory signaling, while also preventing NFkB activation
and secretion of inflammatory mediators, which further prevents inflammatory responses.
DAMPs activate the innate immune system. CD24 binds to both DAMPs and Siglec G/10
to regulate immune responses.CD24/Siglec G/10 interaction plays a key role in a number
of immune-mediated diseases including graft-versus-host disease (GvHD), multiple sclerosis
and rheumatoid arthritis.;
UNII : FN12T66RMN;
CAS number : 2574508-57-7;
Molecule name : MK-7110;
NCI Metathesaurus CUI : CL504552;
Origin ID : C125903;
UMLS CUI : C5667150;
Semantic type(s)
- concept_is_in_subset
- has_target
