Preferred Label : Etidronate-Cytarabine Conjugate MBC-11;
NCIt synonyms : Etidronate-ara-C Conjugate MBC-11;
NCIt related terms : MBC-11;
NCIt definition : A synthetic conjugate composed of the bisphosphonate etidronate linked to the cytostatic
agent and antimetabolite cytarabine, with potential antineoplastic and antiresorptive
activities. Upon intravenous administration of the etidronate-cytarabine conjugate
MBC-11, the etidronate moiety targets bone and the two moieties are released upon
hydrolysis. Etidronate binds to hydroxyapatite crystals in bone tissues and prevents
its resorption. This prevents bone destruction and induces bone cell mineralization.
In addition, the bone-targeting nature of this agent allows for the accumulation of
cytarabine in bone tissue, where it is able to exert its antitumor effect locally
by competing with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis,
while reducing systemic exposure. This leads to a destruction of bone-associated tumor
cells, an inhibition of tumor cell proliferation and bone metastasis, and prevents
tumor-mediated bone destruction.;
UNII : 4M53T688S5;
CAS number : 332863-86-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 332863-86-2
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G-SRS /a ;
Molecule name : MBC-11;
NCI Metathesaurus CUI : CL504550;
Origin ID : C125901;
UMLS CUI : C4287736;
Semantic type(s)
- concept_is_in_subset
