Preferred Label : Triazinate;
NCIt synonyms : Bakers Antifolate; ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl
fluoride; ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,
5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1)(9CI); ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl
fluoride (1:1)(8CI); BAF; ethanesulfonic acid compound with 3-((2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy)methyl)-N,N-dimethylben
zamide (1:1); alpha-(2-chloro-4-(4,6-diamino-2,2-dimethyl-s-trizin-1(2H)-yl)phenoxy)-N,N-dimethyl-m-toluamide
ethanesulfonic acid; Baker's Antifol; Baker's Antifolate; Ethanesulfonic Acid Compound; Soluble Baker's Antifol; Bakers Antifol; TZT;
NCIt related terms : Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl
fluoride (1:1) (8CI); Baker's Antifol soluble; Benzenesulfonyl fluoride, 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenyl]butyl]-,
monoethanesulfonate (9CI); Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,
5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (9CI);
NCIt definition : A synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate
agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate
reductase (DHFR), resulting in decreased tetrahydrofolate production and interference
with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate
forms. Triazinate also inhibits the transport of folates and may be selectively toxic
to MTX-resistant tumor cells. (NCI04);
UNII : DD99Y262WC;
InChIKey : HKPVIFTWECXNPY-UHFFFAOYSA-N;
CAS number : 41191-04-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 41191-04-2
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G-SRS /a ;
NSC code : 139105;
Codes from synonyms : NSC0127755; NSC0113423; NSC0139105;
Origin ID : C1258;
UMLS CUI : C0077008;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
