Preferred Label : Anti-CD33 Antibody-drug Conjugate IMGN779;
NCIt synonyms : ADC IMGN779; Anti-CD33 ADC IMGN779;
NCIt related terms : IMGN-779;
NCIt definition : An antibody-drug conjugate (ADC) consisting of the humanized monoclonal antibody Z4681A
conjugated, via a cleavable disulfide linker, to the cytotoxic DNA alkylating agent
DGN462, which is an indolino-benzodiazepine dimer containing a mono-imine moiety,
with potential antineoplastic activity. The monoclonal antibody portion of anti-CD33
monoclonal antibody-DGN462 conjugate IMGN779 specifically binds to the cell surface
antigen CD33 expressed on myeloid leukemia cells; upon internalization, the DGN462
moiety is released, and covalently binds to and alkylates DNA, thereby causing cell
cycle arrest, apoptosis and inhibition of cell growth in myeloid leukemia cells that
express CD33. CD33 is expressed on normal non-pluripotent hematopoietic stem cells
and myeloid leukemia cells.;
UNII : YE6R3UY9IV;
Molecule name : IMGN779;
NCI Metathesaurus CUI : CL504373;
Origin ID : C125717;
UMLS CUI : C4085966;
Semantic type(s)
- concept_is_in_subset
- has_target
