Preferred Label : Treosulfan;
NCIt synonyms : Treosulphan; Tresulfon; L-Threitol 1,4-dimethanesulfonate; (S-(R*,R*))-1,2,3,4-butanetetrol,1,4-dimethanesulfonate;
NCIt related terms : 1,2,3, 4-Butanetetrol, 1,4-dimethanesulfonate, [R-(R*,S*)]-; Dihydroxybusulfan;
NCIt definition : The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive,
and antineoplastic activities. Under physiological conditions, treosulfan converts
nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide
intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA
interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated
doses, this agent also exhibits myeloablative and immunosuppressive activities.;
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to the family of drugs called alkylating agents.;
UNII : CO61ER3EPI;
InChIKey : YCPOZVAOBBQLRI-WDSKDSINSA-N;
CAS number : 299-75-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 299-75-2
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G-SRS /a ;
Drug name : Ovastat; Trecondi;
Chemical formula : C6H14O8S2;
NSC code : 39069;
Codes from synonyms : NSC0094160; CDR0000045243; NSC0039069; 515;
Origin ID : C1257;
UMLS CUI : C0076959;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
