Preferred Label : Autologous Interferon-producing Killer Dendritic Cells;
NCIt synonyms : Autologous IKDC-like Cells; Autologous IKDC;
NCIt definition : A preparation of autologous dendritic cells (DC) with a molecular expression profile
similar to both natural killer (NK) cells and DCs, with potential antineoplastic activity.
Autologous interferon-producing killer dendritic cells (IKDCs) are characterized by
double-negative expression of CD3 and CD19; these cells also express low levels of
CD11 and are positive for B220. They are distinguished from plasmacytoid DCs (pDCs)
by the absence of lymphocyte antigen 6C (Ly6C, Gr-1) expression. IKDCs produce interferon
gamma (IFN-gamma) and interleukin (IL) -12, and are able to kill typical NK target
cells using NK receptors while retaining DC-like antigen-presenting activity. Upon
administration of the autologous IKDCs, these cells secrete high levels of IFN-gamma
and, when in contact with tumor cells, mediate TNF-related apoptosis-inducing ligand
(TRAIL)-dependent direct lysis of tumor cells. The resulting apoptotic tumor antigens
may be presented by the IKDCs, thus activating the immune system to exert a cytotoxic
T-lymphocyte (CTL) response to further eliminate tumor cells.;
NCI Metathesaurus CUI : CL504347;
Origin ID : C125667;
UMLS CUI : C4086008;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
