Preferred Label : MnSOD Mimetic BMX-001;
NCIt synonyms : Manganese (III) ortho N-Butoxyethylpyridylporphyrin; Mitochondrial Manganese Superoxide Dismutatse Mimetic BMX-001; MnTnBuOE-3-PyP 5 ; Manganese Butoxyethyl Pyridyl Porphyrin; Manganese(5 ), ((2,2',2'',2'''-(21H,23H-porphine-5,10,15,20-tetrayl-kappaN21,kappaN22,kappaN23,kappaN24)tetrakis(1-(2-butoxyethyl)pyridiniumato))(2-))-,
Chloride (1:5), (sp-4-1)-; Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin;
NCIt related terms : BMX-001;
NCIt definition : A third generation, cationic, lipophilic, manganese (Mn) and porphyrin-based mimetic
of the human mitochondrial manganese superoxide dismutase (MnSOD), with antioxidant
and potential chemoprotective activities. Upon administration, MnSOD mimetic BMX-001
is internalized by cells and mimics the activity of MnSOD by scavenging reactive oxygen
species (ROS), such as superoxide anion, hydrogen peroxide, and hydroxyl radical.
This prevents oxidative damage to macromolecules such as DNA and minimizes oxygen
free radical-related chemotoxicity in normal tissues. This agent was designed to be
more lipophilic and less toxic than first and second generation Mn-porphyrin mimetics.;
UNII : MIJ02RO47F;
CAS number : 1379783-91-1;
Molecule name : BMX-001;
Origin ID : C125666;
UMLS CUI : C4086591;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
