Preferred Label : Methotrexate-Encapsulating Autologous Tumor-Derived Microparticles;
NCIt synonyms : MTX-ATMP;
NCIt definition : A suspension of autologous tumor-derived microparticles (ATMP), that are harvested
from a patient with malignant pleural effusion, encapsulating the antimetabolic drug
methotrexate (MTX), with potential anticancer activity. Although the exact mechanism(s)
of action through which this agent exerts its effect has yet to be fully elucidated,
upon administration of MTX-ATMP, the MTX moiety is released and internalized by tumor
cells. It then binds to and inhibits the enzyme dihydrofolate reductase. This results
in the inhibition of purine nucleotide synthesis and leads to decreased synthesis
of both DNA and RNA, which induces cell death. Presumably, the encapsulation of MTX
by the ATMP improves its bioavailability and decreases its toxicity.;
NCI Metathesaurus CUI : CL504342;
Origin ID : C125656;
UMLS CUI : C4086569;
Semantic type(s)
- concept_is_in_subset
