Preferred Label : Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes;
NCIt synonyms : Anti-PD-1 Antibody Expressing Pluripotent Killer T-Cells; Anti-PD-1 Antibody Expressing Pluripotent Killer T-Lymphocytes; PIK-PD-1; Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Cells; Anti-PDCD1 Antibody Expressing Pluripotent Killer T-Cells; Anti-PDCD1 Antibody Expressing Pluripotent Killer T-Lymphocytes;
NCIt definition : A specific population of pluripotent killer (PIK) T-cells that have been induced to
express high levels of antibodies against the negative immunoregulatory human cell
surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential
antitumor activity. Although the exact mechanism(s) of action through which PIK-PD-1
cells exert their effects has yet to be elucidated, upon infusion, these cells secrete
antibodies that target PD-1 expressed on the surface of activated T-cells and tumor
cells. This may block the interaction of PD-1 with its ligands, programmed cell death
1 ligand 1 (PD-L1, PD-1L1; CD274) and PD-1 ligand 2 (PD-L2, PD-1L2; CD273). The inhibition
of ligand binding prevents PD-1-mediated signaling and results in both T-cell activation
and the induction of T-cell-mediated immune responses against tumor cells. PD-1, an
immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively
regulates T-cell activation; PD-L1 is overexpressed on certain cancer cells, and PD-L2
is primarily expressed on antigen presenting cells (APCs).;
NCI Metathesaurus CUI : CL504340;
Origin ID : C125654;
UMLS CUI : C4085984;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
