Preferred Label : Liposomal Bupivacaine;
NCIt synonyms : Bupivacaine Liposome Injectable Suspension;
NCIt definition : A liposome-encapsulated formulation of bupivacaine, which is an amide-type, long-acting
local anesthetic. Upon administration, bupivacaine reversibly binds to specific sodium
ion channels in the neuronal membrane, resulting in both a decrease in the voltage-dependent
membrane permeability to sodium ions and membrane stabilization. This leads to inhibition
of both depolarization and nerve impulse conduction, and a reversible loss of sensation.
Compared to bupivacaine alone, liposomal delivery increases the duration of local
anesthetic action and delays the peak plasma concentration of bupivacaine due to its
slow release from the liposome.;
Drug name : Exparel;
Origin ID : C125652;
UMLS CUI : C4086546;
Semantic type(s)
- concept_is_in_subset
