Preferred Label : Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes;
NCIt synonyms : Anti-ERBB2 Antibody Expressing Pluripotent Killer T-Cells; PIK-HER2; Anti-ERBB2 Antibody Expressing Pluripotent Killer T-Lymphocytes; Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Cells; Anti-HER2 Antibody Expressing Pluripotent Killer T-Cells; Anti-HER2 Antibody Expressing Pluripotent Killer T-Lymphocytes;
NCIt definition : A specific population of pluripotent killer (PIK) T-cells that have been induced to
express high levels of antibodies against human epidermal growth factor receptor 2
(ERBB2; HER2), with potential antitumor activity. Although the exact mechanism(s)
of action through which PIK-HER2 cells exert their effects has yet to be elucidated,
upon infusion, these cells secrete antibodies targeting HER2 expressed on the surface
of tumor cells. This may inhibit HER2-dependent signaling, which may lead to inhibition
of cellular proliferation and differentiation. Additionally, these cells may stimulate
the host immune system to mount both a highly-specific cytotoxic T-lymphocyte (CTL)
response and antibody-dependent cell cytotoxicity (ADCC) directed against HER2-overexpressing
tumors, which leads to tumor cell lysis. HER2 is a member of the epidermal growth
factor receptor (EGFR) family of receptor tyrosine kinases and is frequently overexpressed
in solid tumors.;
NCI Metathesaurus CUI : CL504332;
Origin ID : C125633;
UMLS CUI : C4085971;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
