Preferred Label : Opolimogene Capmilisbac;
NCIt definition : A proprietary, live-attenuated, double-deleted (LADD) strain of the Gram-positive
bacterium Listeria monocytogenes (Lm) encoding multiple, as of yet undisclosed, tumor-associated
antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon
intravenous administration, opolimogene capmilisbac is taken up by antigen-presenting
cells (APCs), including dendritic cells (DCs). The TAAs are subsequently expressed
by the APCs and then processed and presented to the immune system by both major histocompatibility
complex (MHC) class I and II molecules. This activates the immune system and leads
to the recruitment and activation of cytotoxic T-lymphocytes (CTLs) against the TAA-expressing
tumor cells, eventually resulting in tumor cell lysis. Two genes contributing to the
virulence of Lm have been removed to minimize the risk of infection.;
UNII : 2O95SM11L5;
Molecule name : JNJ-809; JNJ-64041809; ADU-741;
NCI Metathesaurus CUI : CL504330;
Origin ID : C125631;
UMLS CUI : C4086549;
Semantic type(s)
- concept_is_in_subset
