Preferred Label : Carbon C 14 Anlotinib Hydrochloride;
NCIt synonyms : 14C-labeled Anlotinib Hydrochloride; [14C] Anlotinib Hydrochloride;
NCIt definition : A radioconjugate composed of the orally bioavailable hydrochloride salt form of anlotinib,
a receptor tyrosine kinase (RTK) inhibitor, labeled with the radioisotope carbon C
14, with potential use for evaluating the pharmacokinetic profile of anlotinib. Upon
administration of carbon C 14 anlotinib hydrochloride, anlotinib targets multiple
RTKs, including vascular endothelial growth factor receptor type 2 (VEGFR2) and type
3 (VEGFR3). This agent may both inhibit angiogenesis and halt cell growth in tumor
cells that overexpress these RTKs. Labeling of anlotinib with the radioactive tracer
carbon C 14 permits the evaluation of this agent's pharmacokinetic profile, including
its absorption, distribution, metabolism, and excretion (ADME).;
NCI Metathesaurus CUI : CL504326;
Origin ID : C125624;
UMLS CUI : C4086117;
Semantic type(s)
- concept_is_in_subset
