Crofelemer - CISMeF

Preferred Label : Crofelemer;

NCIt definition : An oligomeric proanthocyanidin extracted from the latex produced by the tree Croton lechleri (Euphorbiaceae), with antidiarrheal, and potential antiviral and antimicrobial activities. Upon oral administration, crofelemer acts locally within the gastrointestinal (GI) tract by inhibiting both the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion (Cl-) channel and the calcium-activated Cl- channel (CaCC) expressed on the luminal surface of enterocytes. This inhibits the secretion of chloride ions into the intestinal lumen and prevents high volume water loss. By normalizing Cl- and water balance in the intestines, crofelemer relieves secretory diarrhea.;

UNII : PY79D6C8RX;

CAS number : 148465-45-6;

Drug name : Virend; Fulyzaq;

Molecule name : SP-303; SP 303;

Details

Origin ID

C125392;

UMLS CUI

C2744960;

Automatic exact mappings (from CISMeF team)
- crofelemer [ATC Code]
Currated CISMeF NLP mapping
- Crofelemer (substance) [SNOMED CT concept]
- crofelemer [MeSH concept]
- crofelemer [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Crofelemer (substance) [SNOMED CT concept]
- Product containing crofelemer (medicinal product) [SNOMED CT concept]
- crofelemer [MeSH Supplementary Concept]
- crofelemer [MeSH concept]
- crofelemer [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients