Preferred Label : BET Inhibitor GSK2820151;
NCIt definition : An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family
of proteins, with potential antineoplastic activity. Upon oral administration, the
BET inhibitor GSK2820151 binds to the acetylated lysine recognition motifs in the
bromodomains of BET proteins, thereby preventing the interaction between the BET proteins
and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention
of the expression of certain growth-promoting genes may lead to an inhibition of tumor
cell growth. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional
regulators that play an important role during development and cellular growth.;
Molecule name : GSK 2820151; GSK2820151;
NCI Metathesaurus CUI : CL504160;
Origin ID : C125391;
UMLS CUI : C4087028;
Semantic type(s)
- concept_is_in_subset
- has_target
