Tilsotolimod Sodium

Preferred Label : Tilsotolimod Sodium;

NCIt synonyms : TLR9 Agonist IMO-2125;

NCIt definition : The sodium salt form of tilsotolimod, a proprietary synthetic oligonucleotide-based agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon administration, tilsotolimod binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways, activates B-cells and pDCs, and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.;

UNII : I6CNU8SY0F;

CAS number : 2089768-67-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2089768-67-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : IMO-2125; IMO 2125;

NCI Metathesaurus CUI : CL503920;

Details

Origin ID

C125080;

UMLS CUI

C4743553;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Tilsotolimod [NCIt concept]
has_target
- Toll-Like Receptor 9 [NCIt concept]
is_salt_form_of
- Tilsotolimod [NCIt concept]

Keyword's position in hierarchy(ies) :

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