NCIt definition : The sodium salt form of tilsotolimod, a proprietary synthetic oligonucleotide-based
agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity.
Upon administration, tilsotolimod binds to and activates TLR9 expressed by plasmacytoid
dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways, activates
B-cells and pDCs, and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response
against tumor cells. TLR9 is a member of the TLR family, which plays a fundamental
role in pathogen recognition and activation of innate immunity.;
Semantic type(s)