NCIt related terms : Anti-KIR3DL2 Monoclonal Antibody IPH4102;
NCIt definition : A humanized monoclonal antibody against the immune receptor human killer cell immunoglobulin-like
receptor, three domains, long cytoplasmic tail, 2 (KIR3DL2), with potential immunomodulating
and antineoplastic activities. Upon administration, lacutamab binds to KIR3DL2 expressed
on certain tumor cells. This recruits natural killer (NK) cells and leads to lysis
of KIR3DL2-expressing tumor cells. In addition, IPH4102 induces antibody-dependent
cellular cytotoxicity (ADCC), thereby further eliminating tumor cells. KIR3DL2, a
tumor-associated antigen (TAA) and inhibitory receptor of the KIR family, is specifically
expressed in most subtypes of cutaneous T-cell lymphomas (CTCL) and expressed only
on a fraction of normal NK cells.;
UNII : N8O7MY0VNS;
CAS number : 2187368-16-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2187368-16-5
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