Preferred Label : Iodine I 131 Tenatumomab;
NCIt synonyms : 131I-Tenatumomab;
NCIt definition : A radioimmunoconjugate of tenatumomab, a murine monoclonal antibody targeting the
tumor-associated antigen (TAA) tenascin-C (TNC), labeled with iodine I 131, with potential
antineoplastic activity. The antibody moiety of iodine I 131 tenatumomab binds to
TNC, thereby delivering a cytotoxic dose of iodine I 131 specifically to tumors expressing
TNC. TNC, an extracellular matrix protein, is upregulated in a variety of tumor cell
types; it plays a key role in invasion, tumor cell proliferation and immune evasion.;
NCI Metathesaurus CUI : CL503842;
Origin ID : C124996;
UMLS CUI : C4086527;
Semantic type(s)
- concept_is_in_subset
