Intrachromosomal Amplification of Chromosome 21

Preferred Label : Intrachromosomal Amplification of Chromosome 21;

NCIt related terms : iAMP21;

NCIt definition : A cytogenetic abnormality that refers to the allelic gain of an internal part of chromosome 21. It is a rare high-risk chromosomal abnormality that occurs in approximately 2-5% of pediatric patients with B-cell precursor Acute Lymphoblastic Leukemia. This abnormality has been associated with a poor outcome in patients treated by standard protocols.;

Details

Origin ID

C124874;

UMLS CUI

C4086524;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
concept_is_in_subset
- ALL Authorized Value Terminology [NCIt concept]
- ALL Molecular Analysis Table [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
cytogenetic_abnormality_involves_chromosome
- Human Chromosome 21 [NCIt concept]
is_cytogenetic_abnormality_of_disease
- B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21 [NCIt concept]
- B Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 21 [NCIt concept]

Keyword's position in hierarchy(ies) :

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