NCIt definition : An inhibitor of the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing
protein 3 (TIM-3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune
checkpoint inhibitory and antineoplastic activities. Upon administration, sabatolimab
binds to TIM-3 expressed on certain immune cells, including tumor infiltrating lymphocytes
(TILs). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes
and enhances cytotoxic T-cell-mediated tumor cell lysis resulting in a reduction in
tumor growth. TIM-3, a transmembrane protein expressed on certain T-cells, is associated
with tumor-mediated immune suppression.;