" /> Sabatolimab - CISMeF





Preferred Label : Sabatolimab;

NCIt synonyms : Anti-TIM3 Checkpoint Inhibitor MBG453; Anti-TIM-3 Monoclonal Antibody MBG453;

NCIt definition : An inhibitor of the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, sabatolimab binds to TIM-3 expressed on certain immune cells, including tumor infiltrating lymphocytes (TILs). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis resulting in a reduction in tumor growth. TIM-3, a transmembrane protein expressed on certain T-cells, is associated with tumor-mediated immune suppression.;

UNII : 3L7R886Y06;

CAS number : 2252262-24-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2252262-24-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MBG 453; MBG453;

NCI Metathesaurus CUI : CL503065;

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15/05/2024


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