Preferred Label : Carbon C 14 Lenvatinib Mesylate;
NCIt synonyms : 14C Lenvatinib Mesylate; 14C-lenvatinib Mesylate;
NCIt definition : A radioconjugate composed of the orally bioavailable mesylate salt form of lenvatinib,
a receptor tyrosine kinase (RTK) inhibitor, labeled with the radioisotope carbon C
14, with potential use for evaluating the pharmacokinetic profile of lenvatinib. Upon
administration of carbon C14 lenvatinib mesylate, lenvatinib targets and binds strongly
to multiple RTKs, including vascular endothelial growth factor receptor 1 (VEGFR1;FLT1),
VEGFR2 (KDR), VEGFR3 (FLT4), fibroblast growth factor receptor 1 (FGFR1), FGFR2, FGFR3,
and FGFR4, platelet derived growth factor receptor alpha (PDGFRa), KIT, and RET. This
inhibits growth of tumor cells that overexpress these RTKs. Labeling of lenvatinib
with the radioactive tracer carbon C 14 permits the evaluation of lenvatinib's pharmacokinetic
profile, including its absorption, distribution, metabolism, and excretion (ADME).;
NCI Metathesaurus CUI : CL503027;
Origin ID : C124797;
UMLS CUI : C4086118;
Semantic type(s)
- concept_is_in_subset
