Preferred Label : Cobiprostone Spray;
NCIt synonyms : Cobiprostone Oral Spray; SPI-8811 Spray;
NCIt definition : A topical spray formulation containing the prostone cobiprostone, a type 2 chloride
channel (ClC-2) agonist, with potential mucosal protective and anti-mucositis activities.
Upon administration of cobiprostine via a spray into the oral cavity, cobiprostone
specifically binds to and activates the ClC2 channel located on the mucosal membrane.
This activates the epithelial ClC2 channel, enhances secretion of chloride, and promotes
epithelial barrier repair. This prevents or reduces mucosal injury and reduces mucositis.
ClC2 plays a key role in the protection of mucosal barrier function.;
Origin ID : C124660;
UMLS CUI : C4086205;
Semantic type(s)
- concept_is_in_subset
