Preferred Label : ATM Kinase Inhibitor AZD0156;
NCIt related terms : AZD-0156;
NCIt definition : An orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with
potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration,
AZD0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and
ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA
damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing
tumor cells. In addition, AZD0156 sensitizes tumor cells to chemo- and radiotherapy.
ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell
types; it is activated in response to DNA damage and plays a key role in DNA-strand
repair.;
UNII : P5T0XWC07Z;
CAS number : 1821428-35-6;
Molecule name : AZD0156;
NCI Metathesaurus CUI : CL502880;
Origin ID : C124648;
UMLS CUI : C4085925;
Semantic type(s)
- UMLS correspondences (same concept)
- AZD0156 [MeSH Supplementary Concept]
- concept_is_in_subset
