Preferred Label : Anti-nf-P2X7 Antibody Ointment BIL-010t;
NCIt synonyms : BSCT 10 % Ointment;
NCIt definition : An ointment formulation composed of a purified sheep immunoglobulin G (IgG) antibody
against the non-functional form of the purinergic P2X7 receptor (nf-P2X7), with potential
antineoplastic activity. Upon topical application of the anti-nf-P2X7 antibody ointment
BIL-010t, the antibody binds to nf-P2X7 and inhibits its antiapoptotic activity. This
may induce apoptosis and inhibit the growth of nf-P2X7-overexpressing cancer cells.
P2X7, an ATP-gated cation-selective channel, plays a role in the induction of apoptosis;
nf-P2X7, is upregulated in a variety of cancer cell types while not expressed on normal,
healthy cells and is unable to form a large transmembrane, apoptotic pore upon exposure
to ATP and prevents apoptosis.;
Molecule name : BIL-010t;
NCI Metathesaurus CUI : CL502879;
Origin ID : C124647;
UMLS CUI : C4085988;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
