Preferred Label : Substantia Nigra;
NCIt related terms : BRAIN, SUBSTANTIA NIGRA;
NCIt definition : A large cell mass extending forward, over the dorsal surface of the crus cerebri,
from the rostral border of the pons into the subthalamic region. It is composed of
a dorsal stratum of closely spaced pigmented cells, the pars compacta, and a larger
ventral region of widely scattered cells, the pars reticulata. The pars compacta includes
numerous cells that project forward to the striatum (caudate nucleus and putamen)
and contain dopamine, which acts as the primary neurotransmitter at the synaptic endings.
Other, apparently non-dopaminergic cells project to portions of the ventral nucleus
of thalamus, the superior colliculus and reticular formation. The nigrostriatal projection
is reciprocated by a striatonigral fiber system with multiple neurotransmitters, chief
among which is gamma-aminobutyric acid (GABA). The substantia nigra is involved in
the metabolic disturbances associated with Parkinson's disease and Huntington's disease.;
Alternative definition : CDISC: The portion of the midbrain composed of two parts, the pars compacta and pars
reticulata.;
Origin ID : C12453;
UMLS CUI : C0038590;
Anatomic structure is physical part of
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- is_location_of_anatomic_structure
