Preferred Label : TPSB2 wt Allele;
NCIt synonyms : Tryptase Beta 2 (Gene/Pseudogene) wt Allele; Tryptase, Beta-2 Gene; TPS2; Tryptase, Beta Gene; Tryptase, Beta-II Gene; Tryptase, Beta-III Gene; TryptaseC Gene; TryptaseB Gene;
NCIt definition : Human TPSB2 wild-type allele is located in the vicinity of 16p13.3 and is approximately
3 kb in length. This allele, which encodes tryptase beta-2 protein, plays a role in
the proteolytic activity of mast cell granules.;
NCIt note : There are at least two alleles of TPSB2. They exhibit an unusual amount of sequence
variation and were once thought to be two separate genes. (EntrezGene); Tryptase genes are clustered on chromosome 16p13.3 and have several distinct features.
They have a highly conserved 3' UTR, contain tandem repeat sequences at the 5' flank
and 3' UTR, which may regulate mRNA stability, and have an intron immediately upstream
of the initiator Met codon, which separates the transcription initiation site from
the protein coding sequence. (EntrezGene);
GenBank Accession Number : AF099143;
Origin ID : C124247;
UMLS CUI : C4086885;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_plays_role_in_process
