Preferred Label : Bendamustine-containing Nanoparticle-based Formulation RXDX-107;
NCIt related terms : BENDAMUSTINE DODECYL ESTER;
NCIt definition : A nanoparticle-based formulation containing the alkyl ester of bendamustine, a bifunctional
mechlorethamine derivative, encapsulated in human serum albumin (HSA), with potential
alkylating and antineoplastic activities. Upon administration of the alkyl ester bendamustine-containing
nanoparticle formulation RXDX-107, the nanoparticle formulation permits high concentrations
of the alkyl ester of bendamustine be localized at the tumor site. The modified bendamustine
alkylates and crosslinks macromolecules, resulting in DNA, RNA and protein synthesis
inhibition, and, subsequently, apoptosis.;
UNII : 22C7JIO84O;
CAS number : 1456608-94-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1456608-94-8
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G-SRS /a ;
Molecule name : RXDX 107; RXDX-107; CEP-40125;
NCI Metathesaurus CUI : CL498407;
Origin ID : C124053;
UMLS CUI : C4086019;
Semantic type(s)
- concept_is_in_subset
