Preferred Label : Granisetron Hydrochloride Nasal Spray;
NCIt synonyms : GNS; Intranasal Granisetron Hydrochloride; Granisetron HCl Nasal Spray;
NCIt definition : An intranasal formulation containing the hydrochloride salt form of the indazole derivative
granisetron, a selective serotonin (5-hydroxytryptamine; 5-HT) receptor antagonist,
with antinauseant and antiemetic activities. Upon administration to the nostril, granisetron
selectively binds to and inhibits 5-HT subtype 3 receptors (5-HT3R) located peripherally
on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of
the area postrema, which may result in suppression of chemotherapy-induced nausea
and vomiting (CINV).;
NCI Metathesaurus CUI : CL498406;
Origin ID : C124052;
UMLS CUI : C4084752;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
