8-Chloroadenosine

Preferred Label : 8-Chloroadenosine;

NCIt synonyms : Adenosine, 8-Chloro-; 8-Cl-Ado; 8-Chloro-adenosine; 8-Cl-adenosine;

NCIt definition : An antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-ATP), which functions as a ribonucleoside analogue and competes with ATP during transcription. Therefore, this agent causes RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis.;

UNII : PA05MFH3I7;

InChIKey : MHDPPLULTMGBSI-UUOKFMHZSA-N;

CAS number : 34408-14-5;

Details

Origin ID

C124047;

UMLS CUI

C0169868;

Currated CISMeF NLP mapping
- 8-chloroadenosine [MeSH Supplementary Concept]
- 8-chloroadenosine [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 8-chloroadenosine [MeSH Supplementary Concept]
- 8-chloroadenosine [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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